A Step Closer to Personalized Cancer Cure

An article published in the September 6 issue of Science Express discusses the breakthrough achieved by the Johns Hopkins Kimmel Cancer Center scientists who have completed the first draft of the genetic code for breast and colon cancers.

[The study] identifies close to 200 mutated genes, now linked to these cancers, most of which were not previously recognized as associated with tumor initiation, growth, spread or control.

Because no two patients are the same with breast and colon cancer, therapies are very hard to administer. Ultimately, once we know enough about all of the implicated genes, it will be possible to find out which of a particular patient’s genes are affected and treat only those genes. From the BBC Article:

Dr Anna Barker of the National Cancer Institute said: “Maximising the numbers of targets available for drug development in a specific cancer means that patients will ultimately receive more personalized, less toxic therapies.”

She also said: “In the future, scientists hope to be able to tailor plans for preventing or treating cancer to each person’s individual genetic profile. Studies like this can help us to accomplish this goal.”

Read more:

Hypoallergenic cats for sale 3 950$

A perfect example of positively using your brain. A company that, in the era where genetic engineering is blooming, have used their brain to come out with a simple, yet incredibly powerful idea: Breeding. The price of the cats is scandalous, but other than that, it is quite the solution. Way to go.

US biotech firm Allerca says it has managed to selectively breed them by reducing a certain type of protein that triggers allergic reactions.

Read the full article on the BBC site

Pluto will now be known as 134340

On Friday, September 15th 2006, the former planet Pluto was dubbed asteroid number 134340 to reflect its new status as a “dwarf planet.” Personally, I found it a little freaky that the scientific community changed the named so quickly. Plus, we’ll definitively have another thing to add to our list of things to tell our kids when they are older. “Yes, yes, daddy and mommy knew asteroid 134340 as planet Pluto in our young days.” To which he/she will probably respond: “What do I care ? Now, get out of my room.” Ha ha. A day to remember in my opinion.

Meet Pluto, the dwarf planet.

Pluto, the Dwarf PlanetIt is now official. Scientists meeting in Prague have demoted the planet Pluto to the secondary status of dwarf planet. The decision was based on the fact that Pluto’s orbit overlaps with that of Neptune, which disagrees on the third required characteristic of being a planet. In fact, during the same meeting, scientists redefined a planet as a celestial body which

  1. is in orbit around the Sun
  2. is large enough that it takes on a nearly round shape
  3. has cleared its orbit of other objects

We understand the ambiguity when we consider the previous definition of a planet: a celestial body moving in an elliptical orbit round a star. (Oxford Dictionary). A quote from the BBC’s article on the subject explains the history behind the debate:

Pluto’s status has been contested for many years. It is further away and considerably smaller than the eight other “traditional” planets in our Solar System. At just 2,360km (1,467 miles) across, Pluto is smaller even than some moons in the Solar System.

But the real reason for Pluto’s demotion came with a discovery in 2003, which seemed to indicate that if Pluto was in fact a planet, then a number of other celestial bodies should be considered a planet, adding about 20 new planets to our Solar System.

The critical blow for Pluto came with the discovery three years ago of an object currently designated 2003 UB313. After being measured with the Hubble Space Telescope, it was shown to be some 3,000km (1,864 miles) in diameter: it is bigger than Pluto.

One thing is for sure, my kids are now going to have to learn new rhymes for the names of the eight planets of the Solar System: “My Very Expensive Mercedes Just Smashed Up a Nissan”. Or the less common “My Very Elderly Mother Just Sat Upon a Needle”. Gone are the days of ‘New Porches’ and ‘North Poles’. Too sad.

Information on Pluto (From the BBC’s article)

It was named after the god of the underworld in Roman mythology.

Orbits Sun every 248 years
Diameter of 2,360km
Has at least three moons
Rotates every 6.8 days
Gravity about 6% of Earth’s
Surface temperature -233C
Nasa probe visits in 2015

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Fearsome Toothed Whale Fossil Found in Oz

Fossilized Janjucetus hunderiThe fossil studied by Erich M. G. Fitzgerald of the School of Geosciences at Monash University, Clayton, Victoria in Australia is surprising to scientist since it belongs to the family of baleen whales. Modern day baleen whale, the humpback and blue whale for example, are all placid, plankton eaters, which means that they do not have huge teeth that are used to eat prey. In fact, some of the fossil whales had teeth, but were inferred to have fed in a similar manner to living whales. The following excerpt from Fitzgerald’s paper [1] explains their conclusion on the subject:

It thus refutes the notions that all stem mysticetes were filter-feeders, and that the origins and initial radiation of mysticetes was linked to the evolution of filter-feeding. Mysticetes evidently radiated into a variety of disparate forms and feeding ecologies before the evolution of baleen or filterfeeding.

This fossil represents a previously unknown species, named after its teenage finder Staumn Hunter, who noticed it in an exposed boulder while surfing in 1997. The species is believed to have lived about 9 to 25 million years ago after the last common ancestor of the toothed and baleen whales. As I pointed out earlier, the previously found fossil whales did not elucidate the origins and early evolution of baleen whales from their lack of a different manner of feeding. So transitional fossils like this one found in Australia can usually explain many hypotheses scientists have on the subject. This one is no exception.

The phylogenetic context of the new whale indicates that basal mysticetes were macrophagous predators that did not employ filter-feeding or echolocation, and that the evolution of characters associated with bulk filter-feeding was gradual.

Finds like these also present scientists with new hypotheses and new questions to be resolved. For example, how did whales evolve drastically different eating habits more than 34 million years ago ? One thing is for sure, this find will clearly make it into the (children) books on the dangerous and mystical monsters of the Pre-historic times.

Age and Paleontogical Information on the Fossil
  • ERA: Cenozoic
  • PERIOD: Tertiary
  • EPOCH: Oligocene
  • AGE: 23.8 to 33.7 Million Years Ago
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References:
  • [1] Fitzgerald, E.M.G. (2006) A bizarre new toothed mysticete (Cetacea) from Australia and the early evolution of baleen whales, Proceedings of the Royal Society B.
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